Royal Air Force Typhoon FGR4s have conducted a mission with France's air force in a combined operation against an underground arms cache in Syrian territory operated by the IS group, per a report from the UK Ministry of Defence.
The location, located using intelligence, was thought to be containing munitions and bombs, the announcement noted, and was positioned in mountainous terrain just north of Palmyra in the heart of Syria.
"Our aircraft used laser-guided Paveway IV weapons to strike a number of access tunnels leading to the facility... initial indications indicate the strike was effective," the MoD said.
There was no indication of any civilian impact in the operation late on Saturday and every plane involved made a safe return, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - established extremist governance over parts of Syria and Iraq until 2019.
"This strike underscores the UK's leading role, and resolve to work closely with our allies, to eliminate any resurgence of IS and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief the Defence Secretary remarked.
RAF aircraft have conducted surveillance missions over Syria to "prevent any attempted comeback" of IS following its military defeat at the Baghuz confrontation in 2019, the MoD reported.
"I want to thank the personnel of British forces participating in this operation for their expertise and their courage," the Defence Secretary added. "Including them were thousands of British personnel deployed over the holidays. This operation, to eliminate dangerous terrorists who pose a risk to our way of life, shows how our armed forces are prepared to act, throughout the year, ensuring Britain's security at home and strong abroad."
During December, the American forces executed what it described as a "massive strike" targeting Islamic State objectives in the country, subsequent to an assault killed two US troops and a civilian linguist in the Palmyra area.
The United Nations estimates Islamic State still boasts an estimated 5,000 to 7,000 militants in Syria and Iraq.